By J. Robert Cassady M.D. (auth.), J. Robert Cassady M.D. (eds.)
The prognosis of melanoma in a baby is a devastating discovering not just to the fogeys yet frequently to the kid. even if the placement is comparatively effortless to simply accept between adults, it really is tricky to simply accept between young children as a result of their basic helpless kingdom. The advances which have been made within the administration of a kid with melanoma within the final two decades were dramatic in personality. those have happened not just through advantage ofthe contributions from early prognosis and extra certain staging but additionally from the contribu tions made by way of surgical procedure, radiation treatment, and the extra common usage of chemotherapy regimens. This quantity by way of J. Robert Cassady units forth the location of radiation oncology within the administration of the kid with melanoma. Radiation treatment is still a huge and demanding a part of the therapy of this staff of illnesses. The e-book provides the elemental wisdom as regards to pediatric oncology and the way it pertains to radiation remedy. It provides a well timed assessment at the subject and is vital for all radiation oncologists interested by the administration of kids with melanoma. Hamburg/Philadelphia, June 1994 H. -P. HEILMANN LUTHER W. BRADY Preface This e-book offers an intensive overview of the function that radiation remedy presently performs within the administration of so much youth tumors. largely augmented with figures and tables the place applicable, it additionally presents a concise assessment of present diagnostic and healing methods for significant formative years malignancies. broad and updated reference lists are an additional benefit.
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Extra info for Radiation Therapy in Pediatric Oncology
Sample text
The authors suggested that dactinomycin and doxorubicin may have induced a radiation "recall" phenomenon and commented upon the patient's rapid deterioration following rapid withdrawal of a course of methylprednisolone. In 1974, CASTELLINO et al. reported six cases of apparent reactivation oflatent pulmonary radiation injury following rapid withdrawal of a course of steroids (included in MOPP chemotherapy for Hodgkin's disease). The interval between pulmonary radiation and the onset of pulmonary symptoms following steroid withdrawal ranged between 3 months and 6 years.
1987). 29 at death) and compared them with those of 10 unirradiated control patients matched for age and sex who had not been irradiated to the heart. 05). The total number of sections showing more than 25% narrowing was actually slightly During the past decade, anecdotal reports of appar- greater in controls than in the treated patients. ent premature narrowing of coronary vessels in irra- Although the authors concluded that this study diated patients have raised concern about this risk demonstrated radiation-induced coronary artery although most analyses oflarge populations failed to disease, the evidence is of marginal significance, pardemonstrate conclusively that premature coronary ticularly in view of the small number of patients from artery disease was a serious risk in patients treated whom the sections were taken.
The interval between pulmonary radiation and the onset of pulmonary symptoms following steroid withdrawal ranged between 3 months and 6 years. Several retrospective studies have reported on the long-term follow-up of pulmonary function in children treated with radiation and chemotherapy for Wilms' tumor metastatic to the lung. BENOIST et al. (1982) performed sequential pulmonary function tests in 48 patients treated between 1960 and 1976 with actinomycin D and bilateral lung irradiation to a dose of 20 Gy in 21 days (fraction size and beam energy were not mentioned).
