By Heinrich Burkhardt (auth.), Martin Wehling (eds.)
With humans elderly sixty five years and older at present making up the quickest starting to be age workforce during the international, the demographic revolution of an getting older society will necessarily bring about elevated strain to advance a rationalistic and age-tailored means of analysis and remedy one of the aged. As getting older humans usually be afflicted by a number of persistent illnesses and are being handled with a number of drugs simultaneously, undesirable drug interactions happen extra often.
Whereas fresh methods have urged to take away specific medications from the medicine routine to prevent hostile results, Drug treatment for the Elderly underlines either vital and dispensable parts of drug therapy so as to supply an total evaluation of substances compatible for the elderly. In view of the multimorbidity and polypharmacy events skilled by way of aged sufferers, this ebook takes into consideration the designated wishes and specifications proven by means of this crew, therefore serving as a well timed reference for physicians who deal with the aged.
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Additional resources for Drug Therapy for the Elderly
Sample text
Moreover, cohort studies and RCTs frequently do not represent daily practice (“real world”) due to low external validity and exclusion of significant patient groups (Rothwell 2005). Therefore, pharmacovigilance often reveals serious adverse effects years after market introduction of newly developed drugs, and the risk-benefit ratio may shift significantly. This underlines the value of pharmacovigilance systems. Another problem in this context relates to the correct coding and categorization of the large variety of drugs available.
This may be the cause for subsequent intoxications. In this context, NSAIDs are the leading drugs again as they—often in combination with other drugs impairing renal function—may induce acute renal failure. Dangerous drug partners are ACE inhibitors and spironolactone; often a minor gastroenteritis aggravates the situation by dehydration, and as a consequence, even dialysis may become necessary. Another important drug-disease interaction of NSAIDs (which appear most frequently as culprits of disaster in the elderly) relates to the treatment of arterial hypertension.
Low-rate, but nevertheless serious, ADRs are often underreported in studies, and the association of symptoms of health-related problems with drug prescription may remain unclear or missed. Even in randomized controlled studies (RCTs) that are well controlled, monitoring of adverse effects and reporting of these is still often incomplete (Ioannidis and Lau 2001). Moreover, cohort studies and RCTs frequently do not represent daily practice (“real world”) due to low external validity and exclusion of significant patient groups (Rothwell 2005).
