By Dennis P. O'Malley (auth.)
The spleen is an organ which has diversified capabilities together with immunologic and hematologic. The Atlas of Spleen Pathology describes and selectively illustrates the conventional and pathologic stipulations that afflict the spleen. This awesome number of prime quality electronic photographs will materially relief in carrying on with efforts to acknowledge, comprehend, and competently interpret the gross and light-weight microscopic findings in spleens.
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This spleen shows a seemingly normal pattern of white and red pulp. However, this spleen is massively enlarged (> 1 kg), with a relatively proportional expansion of red and white pulp. There are increases in abnormal lymphocytes within both the white and red pulp. (Image courtesy of A. ) Fig. 22 Chronic lymphocytic leukemia. Sections of spleen with a diagnosis of CLL and refractory immune thrombocytopenic purpura. Both would contribute to splenic enlargement. In this case, there is an overall increase in white pulp structures accentuating the miliary appearance, which is seen in many B-cell lymphoma predominantly involving splenic white pulp.
There are two types of blastoid mantle cell lymphomas: pleomorphic type and blastic type. In this case, the cells are large in size with irregular pleomorphic nuclei Lymphoid Neoplasms Plasma Cell Myeloma Fig. 63 Plasma cell myeloma. Gross image of spleen involvement by plasma cell myeloma. In this case, there is a diffuse red pulp pattern, imparting a “beefy” appearance. Myeloma only rarely involves the spleen diffusely, as in this case. (Image courtesy of D. ) Fig. 64 Plasma cell myeloma. High magnification of splenic involvement by plasma cell myeloma.
Low-magnification image of spleen with involvement by CLL. In this typical case, there is an overall increase in the number and size of white pulp nodules 24 3 Lymphoid Neoplasms Fig. 25 Chronic lymphocytic leukemia. In this case, white pulp nodules are enlarged, as well as extension of lymphoid cells along arterioles, replacing the normal PALS region. In this case, there is a pale rim around the lymphoid nodules, raising the differential of residual marginal zone cells or marginal zone differentiation within the CLL cells Fig.
