By Aart Jan van der Lely, Albert Beckers, Adrian Daly, Steven W. Lamberts, David R. Clemmons
This ebook stories the pathophysiology and actual manifestations of acromegaly and discusses the a number of remedies now on hand for the administration of the sufferer with acromegaly. The ebook comprises an considerable variety of illustrations that support to stress issues of specific curiosity, together with radiological, histopathological, and actual prognosis photographs. Sections are dedicated to detailing vital subject matters together with determinants of pathological results of sickness job in acromegaly, person healing offerings and standards for prognosis, and sickness regulate.
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Additional resources for Acromegaly: Pathology, Diagnosis and Treatment
Br Med J 1974; 1:352–355. 49. Bauer W, Briner U, Doepfner W, Haller R, Huguenin R, Marbach P, Petcher TJ, Pless J. SMS 201–995: a very potent and selective octapeptide analogue of somatostatin with prolonged action. Life Sci 1982; 31:1133–1140. 50. Wass JAH, Thorner MO, Morris DV, Rees LH, Mason SA, Jones AE, Besser GM. Long-term treatment of acromegaly with bromocriptine. Br Med J 1977; 1:875–878. 2 The Pituitary Gland: Normal GH/IGF-I Secretion ANATOMY AND STRUCTURE OF THE PITUITARY GLAND The pituitary gland comprises an anterior portion (adenohypophysis) and a posterior portion (neurohypophysis), each of which has a distinct embryonic origin.
GH 54 I. Pathology Figure 19 Plain skull radiographs of the head of the patient shown in Figure 18, demonstrating clearly the effects of fibrous dysplasia and bony deformity on the skull and mandible. Source: A. Beckers and P. Petrossians abuse has the potential to cause acromegaly in those taking excessive doses over a period of years. COMPLICATIONS OF ACROMEGALY Acromegaly is associated with a wide range of pathological effects on nearly all tissues and organs. The complications of acromegaly can be caused by the direct expansion of a tumor, such as optic chiasmal impingement and visual field loss due to suprasellar extension of a macroadenoma (Fig.
8) Etxabe et al. (2) Rajasoorya et al. (9) Swearingen et al. (11) Beauregard et al. (12) Arita et al. (13) Ayuk et al. (14) Holdaway et al. (15) Biermasz et al. 5 23 24 11 50 9 33 50 18 22 24 46 3. Epidemiology, Pathology, and Complications 41 A series of predictors of poor outcomes in acromegaly have been identified, many of which are also predictors of a poor response to therapy. As reviewed by Holdaway and Rajasoorya, these prognostic factors can be divided into those that predict morbidity and those that predict mortality (1).
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