Integrative Human Biochemistry: A Textbook for Medical by Andrea T. da Poian, Miguel A. R. B. Castanho

By Andrea T. da Poian, Miguel A. R. B. Castanho

This publication covers intimately the mechanisms for a way strength is controlled within the human physique. the fundamental ideas that elucidate the reactivity and actual interactions of topic are addressed and quantified with basic techniques. three-d representations of molecules are offered in the course of the publication so molecules will be considered as targeted entities of their form and serve as. The e-book is concentrated at the molecular mechanisms of mobile techniques within the context of human physiological occasions reminiscent of fasting, feeding and physical exertion, within which metabolic law is highlighted. additionally the publication makes use of key ancient experiments that unfolded new innovations in Biochemistry to extra illustrate how the human physique features at molecular point, aiding scholars to understand how medical wisdom emerges.

This e-book also:

· Elucidates the principles of the molecular occasions of life

· &nb

sp; makes use of key historic experiments that unfolded new recommendations in Biochemistry to extra illustrate how the human physique features at molecular point, aiding scholars to understand how clinical wisdom emerges

· presents reasonable representations of molecules in the course of the book

Advance compliment for Integrative Human Biochemistry

“This textbook provid

es a latest and integrative standpoint of human biochemistry and may be a devoted spouse to healthiness scie

nce scholars following curricula within which this self-discipline is addressed. This textbook could be a most valuable software for the instructing community.”

–Joan Guinovart

Director of the Institute for study in Biomedicine, Barcelona, Spain

President-elect of the foreign Union of Biochemistry and Molecular Biology,


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Extra info for Integrative Human Biochemistry: A Textbook for Medical Biochemistry

Sample text

10 Dorothy Mary Crowfoot Hodgkin in her study at home portrayed by Maggi Hambling (oil on canvas, 1985). The four-handed scientist representation symbolizes her unusual working and entrepreneurial capacity. Dorothy Hodgkin made extremely valuable contributions to the advancement of biochemistry. She revealed the structure of cholesterol, penicillin, insulin, and vitamin B12, among other molecules. She also contributed to the refinement of X-ray diffraction spectroscopy to unravel the structure of proteins.

7). The virus has the protein hemagglutinin A (HA) on its surface. This protein mediates virus entry into the host cells by binding to a saccharide, the sialic acid linked to molecules (glycans) present on cell surface, which are known as virus receptor. HA recognizes sialic acid due to a very precise combination of hydrogen bonds and ionic interactions, among others, between well-defined atoms on the protein and atoms on the sialic acid molecule (Fig. 7). These atoms, both the ones in the protein and in the saccharide, are at precise distances and orientations relative to each other so that a unique combination 12 1 Introduction: Life Is Made of Molecules!

Of forces creates a strong binding between them. Influenza A virus may establish contact with many cells in the human body but will only bind to those having sialic acid-containing receptor on its surface (mainly cells of the upper respiratory tract epithelium). Consequently, these are the cells that can be preferentially infected by the virus. Virus–cell attachment (more precisely HA-sialic acid binding) induces virus internalization through endocytosis. The virus is enclosed in a vesicle in the cytosolic space.

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Integrative Human Biochemistry: A Textbook for Medical by Andrea T. da Poian, Miguel A. R. B. Castanho
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