Fibrocytes: New Insights into Tissue Repair And Systemic by Richard Bucala

By Richard Bucala

Because the discovery of the circulating fibrocyte in 1994 as a collagen-producing mobilephone of the peripheral blood, the physiologic and pathologic position of this particular cellphone populaton has grown gradually. This pioneering new publication offers the 1st complete assessment of the position of fibrocytes in wound fix, granuloma formation, antigen presentation, scar formation, and numerous fibrosing problems equivalent to interstitial lung disorder and nephrogenic systemic fibrosis. it is usually discussions of the new reviews at the molecular indications that impression fibrocyte migration, proliferation, and serve as within the context of standard body structure and pathology. The chapters are contributed by way of the best researchers within the box.

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Ch02 FA October 6, 2006 6:28 WSPC/SPI-B408: Fibrocytes: New Insights into Tissue Repair and Systemic Fibroses Fibrocytes: Immunologic Features 31 may serve a critical function in the fibrotic response to chronic inflammation. In summary, fibrocytes purified from wound chambers implanted into mice and from human peripheral blood have been found to express chemokines, hematopoietic growth factors and fibrogenic cytokines. That fibrocytes are such an abundant source of essential cytokines suggests that these cells may play an important role in the control of both the inflammatory and repair phases of the wound healing response.

Peripheral blood fibrocytes are potent primers of naive T cells and thus may play an important role in the initiation of this cascading series of cellular events required for immunity. 34,35 Dendritic cells bearing antigen are thought to sensitize resting CD8+ T cells which then acquire the ability to kill infected targets. However, certain “non-professional” tissue fibroblasts expressing viral proteins are also capable of inducing a strong CD8+ T cell response in vivo without any involvement of host dendritic cells.

38. Gabbiani G. (2003) The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 200: 500–503. 39. Chauhan H, Abraham A, Phillips JRA, et al. (2003) There is more than one kind of myofibroblast: analysis of CD34 expression in benign, in situ, and invasive breast lesions. J Clin Pathol 56: 271–276. 40. Ramaswamy A, Moll R, Barth PJ. (2003) CD34+ fibrocytes in tubular carcinomas and radial scars of the breast. Virchows Archiv 443: 536–540. 41. Kirchmann TTT, Prieto VG, Smoller BR. (1994) CD34 staining pattern distinguishes basal-cell carcinoma from trichoepithelioma.

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Fibrocytes: New Insights into Tissue Repair And Systemic by Richard Bucala
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