Atlas of Diabetes by Jay Skyler

By Jay Skyler

This instruction manual is a useful source for making improvements to the administration of diabetes. Chapters conceal the basics, together with epidemiology, heritage and actual exam, and practical reviews. Diabetes in young ones, teenagers, adults, and geriatrics are addressed. Differential prognosis is emphasised, and evidence-based guidance and patient-specific concerns relief the reader with damage evaluate and care. particularly, the ebook highlights the significance of realizing diabetic signs while opting for the resource of health problems. moreover, the textual content offers the spectrum of therapies for diabetes. The e-book is whole with appendices that specify the evidence-based process used all through and the technological know-how in the back of healing modalities.

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Sample text

Different tissues are known to respond differently to insulin. Although tissue sensitivity to the hormone correlates with the levels of insulin receptors expressed on the plasma membrane, it is clear the assembly of different components of the insulin signaling pathway also confers specificity of insulin action on target cells. Insulin stimulates glucose turnover, favoring its influx into cells, followed by oxidative metabolism to release energy or produce lipids or by nonoxidative metabolism to store glucose as glycogen.

116. Brown MS, Goldstein JL: Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 2008, 7:95–96. 117. Postic C, Girard J: Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 2008, 118:829–838. 118. : Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med 2009, 15:1307–1311. 119. : Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest 2002, 109:1193–1201.

Sawka-Verhelle D, Tartare-Deckert S, White MF, Van Obberghen E: Insulin receptor substrate-2 binds to the insulin receptor through its 86. Jacinto E, Lorberg A: TOR regulation of AGC kinases in yeast and mammals. Biochem J 2008, 410:19–37. Mechanisms of Insulin Action 37 87. : Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 1997, 277:99–101. 88. : Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med 2001, 7:1128–1132.

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Atlas of Diabetes by Jay Skyler
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