By Sudhir Agrawal
Prime researchers provide an authoritative survey and research of the most recent findings at the speedy improvement of antisense oligonucleotides healing and their program in a number of in vivo version structures. The book's high-profile individuals offer well timed money owed in their cutting-edge thoughts, discussing such themes because the synthesis and purification of oligonucleotides, their choice for a selected gene aim, varied equipment of management, and using quite a few telephone strains and cellphone tradition structures. additionally they study questions of mobile uptake, in vitro organic job, in vivo organic task, the pharmacology and pharmacokinetics of oligonucleotides, and the applying of oligonucleotides to the principal worried method.
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Extra resources for Antisense Therapeutics
In this procedure, an indwelling cannula is stereotaxically implanted in the third ventricle and cemented in place. Polyethylene tubing is connected to the cannula, run under the skin, and connected to an Alzet microinfuslon pump implanted subcutaneously between the rat’s shoulder blades. Infusate concentrations >3 mM, administered at 1 pL/h, are toxic. Global CNS depression followed by death routmely occurred within 24 h of infusion initiation. 5 M, however, were well tolerated during a 2-wk period.
And Welch, D. R. (1994) Enhanced metastattc abilny of TNF-a-treated malignant melanoma cells is reduced by mtercellular adhesion molecule- 1 (ICAM- 1, CD54) antisense oligonucleotides. Exp Cell Res 214,23 l-24 1 4 1 Cohen, J S (199 1) Antisense oligodeoxynucleotldes as antiviral agents. Antrvzral Res 16, 121-133. 42. Dolmck, B. J. (1991) Antisense agents m cancer research and therapeutics. Cancer Invest 9, 185-l 94 43 Agrawal, S. (1992) Antisense oligonucleotides as antiviral agents TZBTECZf 10, 152-158 44 Bennett, C.
Neckers, Daniel Geselowitz, Luke Whitesell, and Raymond Bergan Christine Chavany, 1. ). Although attention has been focused recently on the development of antisense ODN as therapeutics for a variety of diseases, including cancer (4), systemic application of ODN to treat tumors other than those of the hematopoietic system presents several problems, not least ofwhich is the ability of systemically administered antisense to reach distant tumor sites. This is particularly true when considermg tumors of the central nervous system (CNS), such as glioblastomas and HIV-associated B-cell lymphomas.
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