Antisense Therapeutics by Sudhir Agrawal

By Sudhir Agrawal

Prime researchers provide an authoritative survey and research of the most recent findings at the speedy improvement of antisense oligonucleotides healing and their program in a number of in vivo version structures. The book's high-profile individuals offer well timed money owed in their cutting-edge thoughts, discussing such themes because the synthesis and purification of oligonucleotides, their choice for a selected gene aim, varied equipment of management, and using quite a few telephone strains and cellphone tradition structures. additionally they study questions of mobile uptake, in vitro organic job, in vivo organic task, the pharmacology and pharmacokinetics of oligonucleotides, and the applying of oligonucleotides to the principal worried method.

Show description

Read Online or Download Antisense Therapeutics PDF

Best therapy books

Fire Your Therapist: Why Therapy Might Not Be Working for You and What You Can Do about It

Construct the existence you will want with the strong replacement to therapy
"This is a good e-book approximately you attaining top functionality, higher stability, and good fortune. contemplate it as your individual own consultant to getting from strong to nice on your lifestyles. Dr. Siegler truly does what many earlier than have got down to accomplish-bright, bold humans of every age now have a confirmed route to transformation. "
—Stewart Emery, coauthor of the foreign bestsellers good fortune outfitted to final and Do You Matter?
"Dr. Siegler possesses the traits of the easiest catalysts for profound switch: readability, compassion, and the braveness to determine every one patron with fresh eyes. This e-book is the basic advisor for locating your method during the complicated thicket of self-mastery recommendations. "
—Raphael Cushnir, writer of the single factor keeping You again and browsing Your internal Sea
"Finally, a brand new paradigm-that is clean, bold, leading edge, and client-centric-that can yield the lifestyles and profession you will have. With fireplace Your Therapist, Dr. Siegler ushers in a brand new period of self-improvement. "
—Josh Baran, writer of The Tao of Now
"Dr. Siegler stocks the client-centered, goal-directed philosophy of resolution targeted remedy and broadens it. if you happen to need to make an informed selection approximately find out how to in attaining the lifestyles they wish, he anticipates and solutions your questions in a complete and declaring demeanour. "
—Eve Lipchik, codeveloper of resolution centred remedy and writer of past process in resolution concentrated Therapy
Feel like remedy isn't operating for you? want there have been a greater approach to in attaining your objectives? hearth Your Therapist introduces a brand new, holistic method of developing the existence you will have. in line with Dr. Siegler's groundbreaking Spheres of existence training process, this ebook explains how you can flow past the "talking cure" of conventional treatment to a extra inventive, results-oriented method of accomplishing your targets. You'll be encouraged through the reports of consumers who've benefited from Dr. Siegler's confirmed methods.
Fire Your Therapist is the basic step by step consultant for an individual who desires to create a extra winning existence.

Psychotherapy after Brain Injury: Principles and Techniques

  This e-book offers hands-on instruments for addressing the a number of ways in which mind damage can impact mental functioning and overall healthiness. the writer is a pacesetter within the box who interprets her vast medical event into simple but versatile instructions that therapists can adapt for various demanding situations and settings.

Recent Progress in the Study and Therapy of Brain Edema

This factor includes the lawsuits of the newest Inter­ nationwide Symposium on mind Edema, the fifth in a sequence of confer­ ences beginning 1965 in Vienna. The ever given that expanding curiosity during this box won't simply consequence from the truth that - in scientific phrases - the matter isn't solved but, but additionally from the numerous attention-grabbing physiological and biochemical questions final.

Das Unsterblichkeits-Enzym: Die Umkehrung des Alterungsprozesses ist möglich

Die jüngsten Nachrichten aus der medizinisch-biologischen Forschung sind aufregend, ja sensationell: Der Menschheitstraum vom Jungbrunnen - er kann Wirklichkeit werden. Denn durch die sogenannte Telomerase-Induktion kann die Lebensuhr neu eingestellt, immer wieder neu aufgezogen werden. Wir sind der Möglichkeit, bei guter Gesundheit weit über hundert Jahre alt zu werden, ein Stückchen näher gerückt.

Extra resources for Antisense Therapeutics

Sample text

In this procedure, an indwelling cannula is stereotaxically implanted in the third ventricle and cemented in place. Polyethylene tubing is connected to the cannula, run under the skin, and connected to an Alzet microinfuslon pump implanted subcutaneously between the rat’s shoulder blades. Infusate concentrations >3 mM, administered at 1 pL/h, are toxic. Global CNS depression followed by death routmely occurred within 24 h of infusion initiation. 5 M, however, were well tolerated during a 2-wk period.

And Welch, D. R. (1994) Enhanced metastattc abilny of TNF-a-treated malignant melanoma cells is reduced by mtercellular adhesion molecule- 1 (ICAM- 1, CD54) antisense oligonucleotides. Exp Cell Res 214,23 l-24 1 4 1 Cohen, J S (199 1) Antisense oligodeoxynucleotldes as antiviral agents. Antrvzral Res 16, 121-133. 42. Dolmck, B. J. (1991) Antisense agents m cancer research and therapeutics. Cancer Invest 9, 185-l 94 43 Agrawal, S. (1992) Antisense oligonucleotides as antiviral agents TZBTECZf 10, 152-158 44 Bennett, C.

Neckers, Daniel Geselowitz, Luke Whitesell, and Raymond Bergan Christine Chavany, 1. ). Although attention has been focused recently on the development of antisense ODN as therapeutics for a variety of diseases, including cancer (4), systemic application of ODN to treat tumors other than those of the hematopoietic system presents several problems, not least ofwhich is the ability of systemically administered antisense to reach distant tumor sites. This is particularly true when considermg tumors of the central nervous system (CNS), such as glioblastomas and HIV-associated B-cell lymphomas.

Download PDF sample

Antisense Therapeutics by Sudhir Agrawal
Rated 4.11 of 5 – based on 10 votes