By Icon Health Publications, Health Publica Icon Health Publications
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Additional info for Alcohol Abuse - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Sample text
The antagonistic effects of HYPOX on bone formation can be reversed with parathyroid hormone (PTH), which up-regulates IGF-1 expression by bone cells. Based on these findings, our working hypotheses are that alcohol-induced osteoporosis is largely due to decreased IGF-1 expression by osteoblasts, and can be prevented or reversed by treatment with PTH. We propose to test these hypotheses in adult and adolescent female rat models for chronic alcohol abuse by determining changes in bone and mineral metabolism in: (1) HYPOX and intact rats fed alcohol; (2) HYPOX and intact rats fed alcohol and treated with GH; (3) HYPOX and intact rats fed alcohol and treated with IGF-1; and (4) HYPOX and intact rats simultaneously fed alcohol and treated with PTH; and (5) intact rats fed alcohol to induce bone loss and then treated with PTH.
Likewise, important advances have been made in the development of behavioral interventions designed to treat alcohol abuse. While new 28 Alcohol Abuse alcohol abuse therapies have been developed over the last several years, pressures have been developing to identify therapies that are not only efficacious but also cost-effective. Much of this pressure has been driven by managed care, which has placed a premium on economic studies that assess whether the clinical and economic outcomes of new pharmaceutical and behavioral therapies justify their costs.
The proposed research will examine longitudinally from high school to college-age to midlife the evolution and health and social consequences of college and college-age drinking using non-drinkers and individuals who do not attend college as comparison groups. The analytic approach we propose to use permits us to control for unobserved differences among these groups and college drinkers that may bias the estimated effects of college and college-age drinking. " Tobacco use among alcoholics is a major public health problem.
