By Jean-Pierre Despres, Vincenzo Di Marzo
This the world over popular writer group offers a different and thorough research and distillation of the endocannabinoid approach and its dating to belly weight problems, diabetes, and heart problems. The endocannabinoid approach (ECS) performs a tremendous position in cardiometabolic hazard, in addition to modulating power stability, feeding habit, hepatic lipogenesis, and maybe glucose homeostasis. proof means that the ECS is overactive in human weight problems and dyslipidemia. severe to the administration of cardiometabolic possibility, this new, well timed booklet offers functional overviews and administration advice on many very important issues, together with: belly weight problems and the metabolic syndrome the endocannabinoid process and effort stability: capabilities and dysfunctions stomach weight problems, the EC process, and cardiometabolic hazard
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Extra resources for Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk
Osei-Hyiaman D, DePetrillo M, Pacher P, et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest 2005; 115(5):1298– 1305. ˆ e M, Matias I, Lemieux I, et al. Circulating endocannabinoid levels, abdominal adiposity and 34. Cot´ related cardiometabolic risk factors in obese men. Int J Obesity 2007; 31:692–699. ¨ om ¨ L, et al. Effects of rimonabant on metabolic risk factors in overweight 35. Despr´es J-P, Golay A, Sjostr patients with dyslipidemia.
Ross R, Aru J, Freeman J, et al. Abdominal adiposity and insulin resistance in obese men. Am J Physiol Endocrinol Metab 2002; 282(3):E657–E663. 34. Ross R, Freeman J, Hudson R, et al. Abdominal obesity, muscle composition, and insulin resistance in premenopausal women. J Clin Endocrinol Metab 2002; 87(11):5044–5051. 35. Despr´es JP, Moorjani S, Lupien PJ, et al. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis 1990; 10(4):497–511. 36. Bacha F, Saad R, Gungor N, et al.
Despr´es J-P, Golay A, Sjostr patients with dyslipidemia. N Engl J Med 2005; 353(20):2121–2134. 5 Visceral Adiposity and Inflammation Ulf Smith The Lundberg Laboratory for Diabetes Research, Center of Excellence for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden VISCERAL FAT—AN ECTOPIC FAT DEPOT The negative consequences of an excessive accumulation of body fat have long been recognized.
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